一种新型的急性高氨血症病因：真菌血症和脑膜炎。
A novel cause of emergent hyperammonemia: fungemia and meningitis.
作者信息
Hannah William B, Nizialek Gregory, Dempsey Katherine J, Armitage Keith B, McCandless Shawn E, Konczal Laura L
机构信息
Center for Human Genetics, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.
出版信息
Mol Genet Metab Rep. 2021 Nov 25;29:100825. doi: 10.1016/j.ymgmr.2021.100825. eCollection 2021 Dec.
Abstract
Among etiologies of hyperammonemic emergencies, infection must be considered in certain clinical contexts, particularly among immunocompromised individuals. Although is known to be urease-producing, to our knowledge it has not previously been described as a cause of hyperammonemia in patients. We report an immunocompromised man with acute on chronic kidney disease with hyperammonemic crisis due to meningitis and fungemia. It is important to be aware of as a possible cause of hyperammonemia.
摘要
在高氨血症急症的病因中，在某些临床情况下必须考虑感染因素，尤其是在免疫功能低下的个体中。虽然已知[具体病原体未给出]可产生尿素酶，但据我们所知，此前尚未将其描述为患者高氨血症的病因。我们报告一例患有慢性肾脏病急性加重的免疫功能低下男性，因[具体病原体未给出]脑膜炎和真菌血症导致高氨血症危象。认识到[具体病原体未给出]是高氨血症的一种可能病因很重要。
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