Hashemipour Mahin, Hovsepian Silva, Mozafarian Nafiseh, Motaghi Zohreh, Izadikhah Elahe, Maracy Mohammad Reza
Metabolic Liver Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
J Diabetes Metab Disord. 2021 Aug 11;20(2):1281-1288. doi: 10.1007/s40200-021-00854-8. eCollection 2021 Dec.
Glycemic control is traditionally evaluated by monitoring of hemoglobin A1c (HbA1c). This study aims to explore factors related to glycemic control among pediatrics with type 1 diabetes mellitus (T1DM).
This cross-sectional study was conducted among 454 students aged 6-18 years with T1DM in 2018. Demographic and disease related information were collected by a validated questionnaire. Generalized Linear Models (GLM) were used to investigate the association of explanatory variables with HbA1c concentration.
The mean (SD) age of the participants was 11.7(± 3.3) years. The overall prevalence of suboptimal glycemic control was 85.5% (HbA1c ≥ 7%). Results showed that post pubertal children experienced a significant decrease in HbA1c levels compared to prepubertal children (β =-0.83, = 0.003). Underweight children had an increase of 1.32% in HBA1c concentration compared with normal weight children (β = 1.32, = 0.007). We also found that participants with passive smoking had higher HBA1c levels than those without (β = 0.536, = 0.022).
The results indicated that age, BMI and passive smoking and were significantly associated with HbA1c levels. It is suggested that glycemic control is related to multiple factors and the interaction of these factors with each other may have positive or negative effects on it which should be investigated in future studies. Improved understanding in this area could lead to prevention of deterioration in glycemic control.
传统上通过监测糖化血红蛋白（HbA1c）来评估血糖控制情况。本研究旨在探讨1型糖尿病（T1DM）患儿血糖控制的相关因素。
2018年对454名6至18岁的T1DM学生进行了这项横断面研究。通过一份经过验证的问卷收集人口统计学和疾病相关信息。使用广义线性模型（GLM）研究解释变量与HbA1c浓度之间的关联。
参与者的平均（标准差）年龄为11.7（±3.3）岁。血糖控制不佳的总体患病率为85.5%（HbA1c≥7%）。结果显示，与青春期前儿童相比，青春期后儿童的HbA1c水平显著降低（β=-0.83，P=0.003）。与正常体重儿童相比，体重过轻的儿童HBA1c浓度增加了1.32%（β=1.32，P=0.007）。我们还发现，被动吸烟的参与者的HBA1c水平高于未被动吸烟的参与者（β=0.536，P=0.022）。
结果表明，年龄、体重指数和被动吸烟与HbA1c水平显著相关。提示血糖控制与多种因素有关，这些因素之间的相互作用可能对其产生正面或负面影响，未来研究应予以探讨。对此领域的深入了解可能有助于预防血糖控制恶化。
