Robinson Emma L, McKinsey Timothy A
Department of Medicine, Division of Cardiology and Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, CO 80045-0508, USA.
J Cardiovasc Aging. 2022;2. doi: 10.20517/jca.2021.20. Epub 2022 Jan 1.
Severe systemic inflammation in COVID-19 patients can lead to dysfunction of multiple organs, including the heart. Using an ex vivo cardiac organoid system, Mills et al discovered that inhibitors of the chromatin reader protein, bromodomain-containing protein 4, protect cardiomyocytes from COVID-associated "cytokine storm". We briefly review these important findings and highlight the translational significance of the work.
新冠病毒感染患者的严重全身炎症可导致包括心脏在内的多个器官功能障碍。米尔斯等人利用体外心脏类器官系统发现，染色质读取蛋白含溴结构域蛋白4的抑制剂可保护心肌细胞免受新冠相关的“细胞因子风暴”影响。我们简要回顾这些重要发现，并强调这项工作的转化意义。
