铜介导的和无铜的芳基烷基砜的选择性硼化反应。
Cu-mediated Cu-free selective borylation of aryl alkyl sulfones.
作者信息
Huang Mingming, Tang Man, Hu Jiefeng, Westcott Stephen A, Radius Udo, Marder Todd B
机构信息
Institute for Inorganic Chemistry and Institute for Sustainable Chemistry & Catalysis with Boron, Julius-Maximilians-Universität Würzburg, Am Hubland, Würzburg 97074, Germany.
School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.
出版信息
Chem Commun (Camb). 2022 Jan 4;58(3):395-398. doi: 10.1039/d1cc06144e.
A Cu-catalysed borylation of aryl alkyl sulfones was developed for the high yield synthesis of versatile arylboronic esters using a readily prepared NHC-Cu catalyst. In addition, the selective cleavage of either alkyl(C)-sulfonyl or aryl(C)-sulfonyl bonds of a cyclic sulfone Cu-free or Cu-mediated processes generates the corresponding sulfinate salts, which can be further derivatised to provide sulfonyl-containing boronate esters, such as sulfones and sulfonyl fluorides.
开发了一种铜催化的芳基烷基砜硼化反应，用于使用易于制备的NHC-Cu催化剂高产率合成通用的芳基硼酸酯。此外，在无铜或铜介导的过程中，环状砜的烷基（C）-磺酰基或芳基（C）-磺酰基键的选择性裂解会生成相应的亚磺酸盐，这些亚磺酸盐可进一步衍生化以提供含磺酰基的硼酸酯，如砜和磺酰氟。
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