Dutrillaux B, Couturier J
Ann Genet. 1986;29(2):76-81.
Chromosome studies of endometrial carcinomas show several recurrent trisomies or tetrasomies: 1 (long arm), 10, 2, 7, 12, 3 and possibly X (long arm). These chromosomes or chromosome segments carry the majority of the genes coding for enzymes of glucidic metabolism, citrate cycle, and initial steps of nucleotide synthesis. Their excess, which does not appear as a primary event in tumorigenesis, is interpreted as an adaptation of the cancer cells to abnormalities of metabolic pathways. The increase of gene copies, by chromosome duplication, would facilitate the synthesis of enzymes the activity of which is increased. If this view is correct and has a general value, it would mean that, in addition to primary chromosome changes, which may induce oncogene activation, most anomalies, which are obviously secondary, may reflect a disturbance of metabolic pathways coded by housekeeping genes.
1号染色体（长臂）、10号、2号、7号、12号、3号，可能还有X染色体（长臂）。这些染色体或染色体片段携带了大多数编码糖代谢、柠檬酸循环及核苷酸合成起始步骤相关酶的基因。它们的过量并非肿瘤发生中的原发性事件，而是被解释为癌细胞对代谢途径异常的一种适应。通过染色体复制增加基因拷贝数，将有助于合成活性增强的酶。如果这一观点正确且具有普遍意义，那就意味着，除了可能诱导癌基因激活的原发性染色体改变外，大多数明显为继发性的异常情况，可能反映了由管家基因编码的代谢途径的紊乱。
