Gaunt K L, Callaghan J, Roberts D F
Ann Genet. 1986;29(2):82-7.
Karyotype anomalies were found in 9 of 13 non-Hodgkin lymphomas. The observed non-random involvement of chromosomes was non-specific and was associated with chromosome breakpoints rather than recurrent markers. The recurrent markers which were found were similar to those of previously published studies. An attempt to correlate histological classification and chromosome anomalies in published series indicated that there were limited histological associations, the frequency of abnormalities of chromosomes 14 and 18 showing the largest disparity between disease types. Among the breakpoints and translocations found are those known to be associated with oncogene location, and the possibility is raised of an oncogene on 18.
在13例非霍奇金淋巴瘤中，有9例发现了核型异常。观察到的染色体非随机受累情况不具有特异性，且与染色体断点相关，而非与复发标记相关。所发现的复发标记与先前发表的研究中的标记相似。对已发表系列研究中的组织学分类与染色体异常进行相关性分析的尝试表明，组织学关联有限，14号和18号染色体异常的频率在不同疾病类型之间差异最大。在所发现的断点和易位中，有一些已知与癌基因定位相关，这就提出了18号染色体上存在癌基因的可能性。
