可乐定对小鼠中 harmine 诱发震颤的影响：5-羟色胺能系统的参与
Modification by clonidine of harmine-induced tremors in mice: involvement of serotoninergic system.
作者信息
Shukla V K, Garg S K, Kulkarni S K
出版信息
Arch Int Pharmacodyn Ther. 1986 Jul;282(1):50-7.
Clonidine exhibited a dose-dependent protection against harmine-induced tremors in mice. This protective effect was not completely blocked by pretreatment with yohimbine. The serotoninergic (5-HT) agonist quipazine and the uptake inhibitor fluoxetine completely antagonized this effect. On the other hand, the 5-HT antagonist cyproheptadine potentiated the protective effect of sub-effective doses of clonidine. These observations suggest a serotonin-mediated action of clonidine in its antitremor action against harmine-induced tremors.
可乐定对小鼠中因 harmine 诱导的震颤呈现出剂量依赖性保护作用。育亨宾预处理并未完全阻断这种保护作用。5-羟色胺能（5-HT）激动剂喹哌嗪和摄取抑制剂氟西汀完全拮抗了这种作用。另一方面，5-HT 拮抗剂赛庚啶增强了亚有效剂量可乐定的保护作用。这些观察结果表明，可乐定在其对抗 harmine 诱导震颤的抗震颤作用中存在 5-羟色胺介导的作用。
Zotero 插件