Zuppiroli A, Cecchi F, Ciaccheri M, Italiani G, Dolara A, Longo G, Matucci M, Morfini M, Rafanelli D
Clin Cardiol. 1986 Oct;9(10):487-92. doi: 10.1002/clc.4960091004.
Twenty-eight consecutive patients with mitral valve prolapse (MVP), seven of whom had previous cerebrovascular disorders (CVD), were studied for platelet function and coagulation tests. While platelet function tests were found to be normal with the exception of platelet aggregation rate (PAR), there was a significant rise of factors VIII vWF:Ag (Von Willebrand) and (FPA) fibrinopeptide A. Six cases had high levels of both these factors, suggesting the existence of a particular subset of patients with MVP, with a higher risk of thromboembolic episodes, although only three out of seven patients with previous CVD had either FPA or VIII vWF:Ag levels. The broad spectrum of subjects with MVP probably explains the different results obtained when studying platelet function and coagulation factors. Therefore, larger population studies and prolonged follow-up of cases with either coagulation abnormalities similar to the ones found in the present report and/or altered platelet function tests are suggested to discover if it is possible to detect patients with a potential for thromboembolism.
对连续28例二尖瓣脱垂（MVP）患者进行了血小板功能和凝血试验研究，其中7例曾有脑血管疾病（CVD）史。除血小板聚集率（PAR）外，血小板功能试验结果均正常，但因子VIII vWF:Ag（血管性血友病因子）和纤维蛋白肽A（FPA）显著升高。6例患者这两种因子水平均较高，提示存在MVP患者的一个特定亚组，其血栓栓塞发作风险较高，尽管7例曾有CVD的患者中只有3例FPA或VIII vWF:Ag水平升高。MVP患者的广泛范围可能解释了在研究血小板功能和凝血因子时得到的不同结果。因此，建议进行更大规模的人群研究，并对具有本报告中发现的类似凝血异常和/或血小板功能试验改变的病例进行长期随访，以发现是否有可能检测出有血栓栓塞潜在风险的患者。
