Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram extn, Sitapur Road, P.O. Box 173, Lucknow 226031, India.
Academy of Scientific and Innovative Research, Ghaziabad-201002, India.
Org Biomol Chem. 2022 Jan 5;20(2):264-281. doi: 10.1039/d1ob02142g.
Over the recent decades, tremendous interest has developed in the transformation of complex substrates by C-H activation and functionalization. In particular, palladium-catalyzed directing and non-directing group-assisted C-H functionalization has emerged as a powerful avenue to access C-branched glycosides. Due to the extreme complexity, delicate functionalities, and high stability of C-H bonds, site-selective functionalization of carbohydrate under mild conditions is highly desirable. The purpose of this review is to cover most of the recent advances in palladium-catalyzed C(sp) and C(sp)-H bond functionalizations for the synthesis of C-branched glycosides along with future directions.
在最近几十年，人们对通过 C-H 活化和官能团化来转化复杂底物产生了浓厚的兴趣。特别是，钯催化的导向和非导向基团辅助的 C-H 官能团化已经成为一种强大的途径来获得 C-支链糖苷。由于 C-H 键的极端复杂性、精细的官能团和高稳定性，在温和条件下对碳水化合物进行选择性官能团化是非常可取的。本综述的目的是涵盖最近在钯催化的 C(sp)和 C(sp)-H 键官能团化用于合成 C-支链糖苷方面的最新进展，并探讨未来的方向。
