García-López Nallely A, Jiménez-Álvarez Alicia, Murillo-Zamora Efrén
1Instituto Mexicano del Seguro Social, Centro Médico Nacional Sigo XXI, Hospital de Oncología, Programa de Especialidad Médica en Cuidados Paliativos. Ciudad de México, México.
Instituto Mexicano del Seguro Social, Hospital General de Zona No. 1, Servicio de Endocrinología Pediátrica. Villa de Álvarez, Colima, México.
Rev Med Inst Mex Seguro Soc. 2021 Nov 1;59(6):465-472.
Non-alcoholic fatty liver disease (NAFLD) has serious health implications and upward trends of the disease, accompanied by the obesity epidemic worldwide.
To screen for fatty liver in overweight and obese children and evaluate the factors associated with an increased likelihood of presenting a positive-screen result.
In a cross-sectional study, 102 children were recruited at a secondary care medical unit. Serum alanine aminotransferase (ALT) levels were quantified and hepatic ultrasounds were performed; multiple logistic regression models were used to evaluate factors associated with the increased odds of presenting with NAFLD (fatty infiltration on ultrasound and ALT > 52 U/L for boys and > 44 U/L for girls).
The overall prevalence of NAFLD was 10.8%. In multivariate analysis, a waist-to-hip ratio ≥ 1 was associated with increased odds of screening positive for NAFLD (odds ratio (OR) = 4.96, 95% CI 1.17-20.90).
Our findings indicate that one out of ten children with overweight or obesity has data suggestive of NAFLD and is at risk of presenting its consequences on health.
非酒精性脂肪性肝病（NAFLD）对健康有严重影响，且随着全球肥胖症的流行，该疾病呈上升趋势。
筛查超重和肥胖儿童中的脂肪肝，并评估与筛查结果呈阳性可能性增加相关的因素。
在一项横断面研究中，在一家二级医疗单位招募了102名儿童。对血清丙氨酸氨基转移酶（ALT）水平进行定量，并进行肝脏超声检查；使用多元逻辑回归模型评估与NAFLD发病几率增加相关的因素（超声显示脂肪浸润且男孩ALT>52 U/L、女孩ALT>44 U/L）。
NAFLD的总体患病率为10.8%。在多变量分析中，腰臀比≥1与NAFLD筛查呈阳性的几率增加相关（比值比（OR）=4.96，95%置信区间1.17-20.90）。
我们的研究结果表明，每十名超重或肥胖儿童中就有一名的数据提示患有NAFLD，并有出现其健康后果的风险。
