Fevers Unit, Department of Medicine, Korle Bu Teaching Hospital, Accra, Ghana.
School of Biomedical and Allied Health Sciences, University of Ghana, Accra, Ghana.
Afr J AIDS Res. 2021 Dec;20(4):270-276. doi: 10.2989/16085906.2021.1998783.
With the introduction of antiretroviral therapy (ART), many HIV-infected children are growing into adolescence and adulthood. A facility-based cross-sectional study was conducted at the Fevers Unit of one of the teaching hospitals in Ghana. The Morisky Medication Adherence Scale (MMAS-8) and pill count were used to assess adherence, while measured viral load levels of participants were used to assess viral suppression. The rate of viral suppression (<400 copies/ml) was 68.2%. Participants with high MMAS-8 scores were 8.4 times more likely to be virally suppressed compared to those with low MMAS-8 scores (OR = 8.4, = 0.003, 95% CI: 2.11-33.48). The commonest reason for missing doses of their antiretroviral drugs (ARVs) was forgetfulness. Efforts must be made by all stakeholders involved in HIV care to engage adolescents and young adults living with HIV (AYALHIV) on personal and/or group levels to help identify and improve particular ART adherence issues so as to increase viral suppression rates.
随着抗逆转录病毒疗法（ART）的引入，许多感染艾滋病毒的儿童已成长为青少年和成年人。本项基于机构的横断面研究在加纳一所教学医院的发热病房进行。采用 Morisky 用药依从性量表（MMAS-8）和药物计数来评估依从性，同时使用参与者的实际病毒载量水平来评估病毒抑制情况。病毒抑制率（<400 拷贝/毫升）为 68.2%。与 MMAS-8 评分低的参与者相比，MMAS-8 评分高的参与者病毒抑制的可能性高 8.4 倍（OR = 8.4，= 0.003，95%CI：2.11-33.48）。漏服抗逆转录病毒药物（ARV）最常见的原因是健忘。必须由参与艾滋病毒护理的所有利益攸关方做出努力，以便在个人和/或群体层面上与艾滋病毒感染者青少年和年轻人（AYALHIV）接触，以帮助识别和改善特定的 ART 依从性问题，从而提高病毒抑制率。
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