SARS-CoV-2 变异株奥密克戎（B.1.1.529）在刺突蛋白 S 的关键区域增加正电荷的突变呈上升趋势。

SARS-CoV-2 variant Omicron (B.1.1.529) is in a rising trend of mutations increasing the positive electric charge in crucial regions of the spike protein S.

机构信息

Institute of Biochemistry and Biophysics Polish Academy of Sciences, Warsaw, Poland.

出版信息

Acta Biochim Pol. 2021 Dec 14;69(1):263-264. doi: 10.18388/abp.2020_6072.

DOI:10.18388/abp.2020_6072

Abstract

An increase in the positive electric charge of SARS-CoV-2 variant Omicron (B.1.1.529) was reported and the electrostatic interaction between the spike protein S and ACE2 receptor was estimated. The results presented here suggest that electrogenic mutations in specific regions of the S protein and the electrostatic force may facilitate viral infection of the host cell.

摘要

有研究报道称，SARS-CoV-2 变异株奥密克戎（B.1.1.529）的正电荷增加，并对刺突蛋白 S 与 ACE2 受体之间的静电相互作用进行了估算。本研究结果表明，S 蛋白特定区域的致电性突变和静电力可能促进了病毒对宿主细胞的感染。