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严重急性呼吸综合征冠状病毒2（SARS-CoV-2）刺突蛋白上增加的正电荷的演变可能是对人际传播的一种适应。

Evolution of increased positive charge on the SARS-CoV-2 spike protein may be adaptation to human transmission.

作者信息

Cotten Matthew, Phan My V T

机构信息

Medical Research Council-University of Glasgow Centre for Virus Research, 464 Bearsden Road, Glasgow G61 1QH, Scotland, UK.

UK Medical Research Council-Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Plot 51- 59 Nakiwogo Road, P.O Box 49, Entebbe, Uganda, UK.

出版信息

iScience. 2023 Mar 17;26(3):106230. doi: 10.1016/j.isci.2023.106230. Epub 2023 Feb 18.

DOI:10.1016/j.isci.2023.106230
PMID:36845032
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9937996/
Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve and infect individuals. The exterior surface of the SARS-CoV-2 virion is dominated by the spike protein, and the current work examined spike protein biochemical features that have changed during the 3 years in which SARS-CoV-2 has infected humans. Our analysis identified a striking change in spike protein charge, from -8.3 in the original Lineage A and B viruses to -1.26 in most of the current Omicron viruses. We conclude that in addition to immune selection pressure, the evolution of SARS-CoV-2 has also altered viral spike protein biochemical properties, which may influence virion survival and promote transmission. Future vaccine and therapeutic development should also exploit and target these biochemical properties.

摘要

严重急性呼吸综合征冠状病毒2（SARS-CoV-2）持续演变并感染个体。SARS-CoV-2病毒粒子的外表面以刺突蛋白为主，目前的研究考察了SARS-CoV-2感染人类的3年期间刺突蛋白发生变化的生化特征。我们的分析发现刺突蛋白电荷发生了显著变化，从最初的A和B谱系病毒中的-8.3变为目前大多数奥密克戎病毒中的-1.26。我们得出结论，除了免疫选择压力外，SARS-CoV-2的进化还改变了病毒刺突蛋白的生化特性，这可能影响病毒粒子的存活并促进传播。未来的疫苗和治疗方法研发也应利用并针对这些生化特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ce5/10009092/fe9ca66169db/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ce5/10009092/62cbf06c24d6/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ce5/10009092/974613d0d7fa/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ce5/10009092/a8e4347cb68e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ce5/10009092/53af7e064d70/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ce5/10009092/fe9ca66169db/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ce5/10009092/62cbf06c24d6/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ce5/10009092/974613d0d7fa/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ce5/10009092/a8e4347cb68e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ce5/10009092/53af7e064d70/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ce5/10009092/fe9ca66169db/gr4.jpg

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