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选择性D-1激动剂SK&F 38393预处理可增强对选择性D-2多巴胺受体激动剂RU 24213的刻板行为反应。

Stereotyped behaviour in response to the selective D-2 dopamine receptor agonist RU 24213 is enhanced by pretreatment with the selective D-1 agonist SK&F 38393.

作者信息

Mashurano M, Waddington J L

出版信息

Neuropharmacology. 1986 Aug;25(8):947-9. doi: 10.1016/0028-3908(86)90027-4.

DOI:10.1016/0028-3908(86)90027-4
PMID:3490631
Abstract

When given alone, 2.5 mg/kg of the selective D-2 agonist RU 24213 was a threshold dose for the induction of weak stereotyped behaviour, while 15 mg/kg of the selective D-1 agonist SK&F 38393 failed to induce stereotypy. Responses to 2.5 mg/kg RU 24213 were dose-dependently potentiated by 3.0-15.0 mg/kg SK&F 38393, and compulsive stereotypy was only evident in animals receiving the combination treatment. Increasing D-1 dopaminergic activity appears to promote the expression of behaviours initiated through D-2 receptor stimulation.

摘要

单独给予时，2.5毫克/千克的选择性D-2激动剂RU 24213是诱导轻微刻板行为的阈剂量，而15毫克/千克的选择性D-1激动剂SK&F 38393未能诱导出刻板行为。3.0 - 15.0毫克/千克的SK&F 38393可剂量依赖性地增强对2.5毫克/千克RU 24213的反应，且强迫性刻板行为仅在接受联合治疗的动物中明显。增加D-1多巴胺能活性似乎会促进通过D-2受体刺激引发的行为表达。

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