Longostrevi G P
Minerva Med. 1986 Oct 13;77(39):1777-88.
After having outlined the importance of evaluating, in cerebral diseases, the regional cerebral blood flow by means of a non invasive method, the advantages of SPECT with Tc99m HM-PAO compared to the SPECT with radioxenon and iodoamphetamine are point out. The results obtained with this method on 28 different patients, six of with were normal subjects, while the remaining 22 were suffering: six from cerebro vascular disease, four from epilepsy, three from TIA, six from dementia, two from depressive syndrome and one from hemicrania are reported. The comparison of the results with literature references, proves that the tracer employed is definitely superior to TCT, while there is a coincidence with SPECT data obtained with radioxenon and iodoamphetamine. The radiotracer employed can be successfully used, due to its convenient physical-chemical features, in a daily routine, for the evaluation of regional cerebral blood flow in encephalic diagnostics.
在概述了通过非侵入性方法评估脑部疾病中局部脑血流量的重要性之后，指出了用锝99m六甲基丙烯胺肟单光子发射计算机断层扫描（SPECT）与放射性氙和碘安非他明SPECT相比的优势。报告了用该方法对28例不同患者的检查结果，其中6例为正常受试者，其余22例患病：6例患有脑血管疾病，4例患有癫痫，3例患有短暂性脑缺血发作（TIA），6例患有痴呆症，2例患有抑郁综合征，1例患有偏头痛。将结果与文献参考进行比较，证明所使用的示踪剂肯定优于计算机断层扫描（TCT），同时与用放射性氙和碘安非他明获得的SPECT数据相符。由于其便利的物理化学特性，所使用的放射性示踪剂可成功用于日常临床，以评估脑部诊断中的局部脑血流量。
