Differential effect of ischemia on spontaneous and sinusoidal-evoked activity in semicircular canal afferents in the bullfrog.

Spontaneous and sinusoidal-evoked nerve activity in semicircular canal afferent fibers of the bullfrog was evaluated prior to and following the production of ischemia of the labyrinthine arterial supply by mechanical occlusion of the vestibular artery. Neuronal spontaneous firing rates were observed to diminish by up to 100% within 10 min following the onset of ischemia. In most neurons there was a substantial increase in firing rate during the first few minutes. The sensitivity of the fibers to natural stimulation as determined by the gain in their responses to sinusoidal motion also diminished by as much as 75% over the same period. No detectable changes in the membrane potentials of the neurons were observed. The changes in excitability were closely correlated with the changes in spontaneous firing rate, but not all the neurons whose responses changed showed changes in spontaneous activity. Likewise, the relative magnitude of change varied from neuron to neuron.