Machado Edilson S, Ambach Mary A, Caldas José Mp, Wei Jason J, Bredemeier Markus
Serviço de Dor e Cuidados Paliativos - Hospital Nossa Senhora da Conceição, Grupo Hospitalar Conceição, Porto Alegre, 91350-200, Rio Grande do Sul, Brazil.
PhD Candidate, Faculty of Medicine of The University of Porto, Porto, 4200-319, Portugal.
Regen Med. 2022 Jan;17(1):11-22. doi: 10.2217/rme-2021-0019. Epub 2021 Dec 15.
To evaluate the use of a multitarget platelet-rich plasma (PRP) injection approach for the treatment of chronic low back pain (LBP). Forty-six patients with more than 12 weeks of LBP who failed conservative treatments were injected with PRP into the facet joints, intervertebral discs, epidural space and/or paravertebral muscles. Visual analog pain scale and Roland-Morris Disability Questionnaire scores were measured at baseline and predefined intervals. Mean visual analog pain scale was reduced from 8.48 to 5.17 and mean Roland-Morris Disability Questionnaire from 18.0 to 10.98 at 12 weeks (p < 0.001). These statistically significant improvements were sustained over 52 weeks. No adverse effects were observed. Our PRP approach demonstrated clinically favorable results and may be a promising treatment for chronic LBP.
评估多靶点富血小板血浆（PRP）注射方法治疗慢性下腰痛（LBP）的效果。对46例经保守治疗无效且LBP病程超过12周的患者，将PRP注射到小关节、椎间盘、硬膜外间隙和/或椎旁肌。在基线和预定的时间间隔测量视觉模拟疼痛量表和罗兰-莫里斯残疾问卷评分。12周时，视觉模拟疼痛量表平均分从8.48降至5.17，罗兰-莫里斯残疾问卷平均分从18.0降至10.98（p<0.001）。这些具有统计学意义的改善在52周内持续存在。未观察到不良反应。我们的PRP方法显示出临床良好效果，可能是慢性LBP的一种有前景的治疗方法。
