Ophthalmic Surg Lasers Imaging Retina. 2021 Dec;52(12):650-657. doi: 10.3928/23258160-20211118-01. Epub 2021 Dec 1.
To investigate the multimodal imaging features and the clinical associations of arteriolosclerotic plaques in patients with retinal vein occlusion (RVO).
This was a retrospective case series of patients with RVO. Demographic and clinical characteristics were recorded at the time of RVO for each participant. Best-corrected visual acuity and central macular thickness were collected at baseline and observed for 1 year. Arteriolosclerotic plaques were identified on multimodal imaging, and their imaging features were summarized. Differences in demographic and clinical characteristics between eyes with arteriolosclerotic plaques and those with no arteriolosclerotic plaques were reported.
Seventy-five eyes of 75 patients (39 males; mean age, 72.5 years) were included. Arteriolosclerotic plaques were identified in nine eyes (12%) as segmental, yellow, ill-defined creamy lesions in the arterioles' walls. Baseline macular edema was worse in eyes with arteriolosclerotic plaques than in eyes with no plaques (716.5 μm vs 539.7 μm). Arteriolosclerotic plaques did not interfere with blood flow and regressed in three eyes (33%). Eyes with plaques had worse best-corrected visual acuity ( < .001) and lower central macular thickness ( = .02) at 12 months than did eyes with RVO and no plaques.
Arteriolosclerotic plaques suggest an ischemic or inflammatory involvement of the arteriolar branches in eyes with RVO and are associated with severe macular damage. .
本研究旨在探讨视网膜静脉阻塞（RVO）患者的动脉粥样硬化斑块的多模态影像学特征及其临床相关性。
本研究为回顾性病例系列研究，纳入了 RVO 患者。记录每位患者 RVO 时的人口统计学和临床特征。在基线和观察 1 年时收集最佳矫正视力和中心黄斑厚度。在多模态成像上识别动脉粥样硬化斑块，并总结其影像学特征。报告了有动脉粥样硬化斑块的眼与无动脉粥样硬化斑块的眼在人口统计学和临床特征方面的差异。
纳入了 75 例患者的 75 只眼（39 名男性；平均年龄 72.5 岁）。9 只眼（12%）被识别出动脉粥样硬化斑块，表现为动脉壁内节段性、黄色、边界不清的奶油状病变。有斑块的眼在基线时黄斑水肿比无斑块的眼更严重（716.5μm 比 539.7μm）。在 3 只眼中（33%），动脉粥样硬化斑块未干扰血流并消退。有斑块的眼在 12 个月时的最佳矫正视力更差（<0.001），中心黄斑厚度更低（=0.02），与无斑块的 RVO 眼相比。
动脉粥样硬化斑块提示 RVO 眼的小动脉分支存在缺血或炎症受累，并与严重的黄斑损害有关。
