Muddassir Rabia, Idris Abdelrahman, Alshareef Noura, Khouj Ghaidaa, Alassiri Rimaz
Department of Neurology, Internal Medicine, Security Forces Hospital, Makkah, SAU.
Department of Medicine and Surgery, Collage of Medicine, Umm Al-Qura University, Makkah, SAU.
Cureus. 2021 Dec 10;13(12):e20321. doi: 10.7759/cureus.20321. eCollection 2021 Dec.
Coronavirus disease 2019 (COVID-19) pandemic is caused by the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) and since the outbreak, many neurological features and syndromes are reported with this multi-organ viral infection. Lance-Adams syndrome (LAS) also referred to as chronic post hypoxic myoclonus is defined as action myoclonus which can occur as generalized, focal, or multifocal repeated myoclonic motor movements which involve the face, trunk, or extremities and it is one of the neurological complications that are related to COVID-19 infection. LAS is reported as a delayed complication of cardiac arrest, which causes cerebral hypoxia leading to myoclonus. We report a case of a 58-year-old male patient diagnosed as a case of LAS secondary to hypoxia occurring because of COVID-19 without cardiac arrest and to the best of our knowledge it is the second case reported with this similar mechanism. Moreover, we discuss the possible pathophysiological relationship between LAS and COVID-19 and various treatment strategies. Eventually, we review the related articles in the literature regarding the LAS and various types of myoclonus associated with COVID-19 infection.
2019冠状病毒病（COVID-19）大流行由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起，自疫情爆发以来，这种多器官病毒感染出现了许多神经学特征和综合征。兰斯-亚当斯综合征（LAS）也称为慢性缺氧后肌阵挛，定义为动作性肌阵挛，可表现为全身性、局灶性或多灶性反复肌阵挛性运动，累及面部、躯干或四肢，它是与COVID-19感染相关的神经并发症之一。LAS被报道为心脏骤停的延迟并发症，心脏骤停导致脑缺氧进而引发肌阵挛。我们报告一例58岁男性患者，诊断为继发于COVID-19所致缺氧的LAS病例，且无心脏骤停，据我们所知，这是第二例报道的具有类似机制的病例。此外，我们讨论了LAS与COVID-19之间可能的病理生理关系以及各种治疗策略。最后，我们回顾了文献中关于LAS以及与COVID-19感染相关的各种类型肌阵挛的相关文章。
