Adana City Training and Research Hospital, Department of Emergency Medicine - Adana, Turkey.
Adana City Training and Research Hospital, Department of General Surgery - Adana, Turkey.
Rev Assoc Med Bras (1992). 2022 Jan;68(1):67-72. doi: 10.1590/1806-9282.20210771.
This study aimed to investigate the ability of the biomarkers to predict the surgery treatment and mortality in patients above 18 years of age who were hospitalized with the diagnosis of bowel obstruction from the emergency department.
This is a 2-year retrospective study. The patients' demographic data, laboratory parameters on admission to emergency department, treatment modalities, and the length of hospital stay were recorded. Patients were divided into two groups: conservative and surgical treatment. Statistical analysis was performed to investigate the value of biomarkers in predicting mortality and the need for surgery. Data were analyzed using IBM SPSS version 22.
A total of 179 patients were included in this study. Of these, 105 (58.7%) patients were treated conservative and 74 (41.3%) were treated operatively. The elevated procalcitonin (PCT) level, C-reactive protein, blood urea nitrogen-to-albumin ratio, and lactate-to-albumin ratio were significantly correlated with surgical treatment, length of hospital stay, and mortality. procalcitonin threshold value of 0.13 ng/mL was able to predict the need for surgical treatment, with a sensitivity of 79% and a specificity of 70.3%. Procalcitonin threshold value of 0.65 ng/mL was able to predict the mortality rate of the patients, with a sensitivity of 92.9% and a specificity of 78.1%.
Biomarkers, especially procalcitonin, may be useful in bowel obstruction treatment management and may predict mortality.
本研究旨在探讨生物标志物在预测因肠梗阻从急诊科住院的 18 岁以上患者的手术治疗和死亡率方面的能力。
这是一项为期 2 年的回顾性研究。记录患者的人口统计学数据、急诊科入院时的实验室参数、治疗方式和住院时间。患者分为保守治疗和手术治疗两组。进行统计分析以调查生物标志物在预测死亡率和手术需求方面的价值。使用 IBM SPSS 版本 22 进行数据分析。
本研究共纳入 179 名患者。其中 105 名（58.7%）患者接受保守治疗，74 名（41.3%）患者接受手术治疗。降钙素原（PCT）水平、C 反应蛋白、血尿素氮与白蛋白比值和乳酸与白蛋白比值升高与手术治疗、住院时间和死亡率显著相关。降钙素原阈值为 0.13ng/mL 时能够预测手术治疗的需要，其敏感性为 79%，特异性为 70.3%。降钙素原阈值为 0.65ng/mL 时能够预测患者的死亡率，其敏感性为 92.9%，特异性为 78.1%。
生物标志物，特别是降钙素原，可能有助于肠梗阻的治疗管理，并可预测死亡率。
