Rodi I A, Sauer M V, Gorrill M J, Bustillo M, Gunning J E, Marshall J R, Buster J E
Fertil Steril. 1986 Nov;46(5):811-3. doi: 10.1016/s0015-0282(16)49816-x.
Seven women with unruptured tubal pregnancies diagnosed on laparoscopy were treated with methotrexate and citrovorum rescue. Criteria for inclusion in the study were that the level of human chorionic gonadotropin (hCG) be plateaued or rising, that the ectopic pregnancy not exceed 3 X 3 cm, that the tubal serosa be intact, and that there be no active bleeding. The women were followed with serial measurements of hCG, complete blood counts, and liver function tests. All women responded to a single course of therapy. The median time to resolution (from the first day of treatment to when the hCG was undetectable) was 31 days (range, 5 to 50 days). Follow-up hysterosalpingograms were available for five women. Four women demonstrated tubal patency, and one showed a unilateral occlusion on the side of the ectopic. One woman was found to have an intrauterine pregnancy prior to the scheduled time of hysterosalpingogram.
七名经腹腔镜诊断为输卵管妊娠未破裂的女性接受了甲氨蝶呤和亚叶酸救援治疗。纳入该研究的标准为：人绒毛膜促性腺激素（hCG）水平稳定或上升、异位妊娠不超过3×3厘米、输卵管浆膜完整且无活动性出血。对这些女性进行了hCG的系列测量、全血细胞计数和肝功能测试随访。所有女性对单一疗程治疗均有反应。缓解的中位时间（从治疗第一天到hCG检测不到）为31天（范围为5至50天）。五名女性有后续的子宫输卵管造影检查结果。四名女性显示输卵管通畅，一名女性在异位侧显示单侧阻塞。一名女性在预定的子宫输卵管造影检查时间之前被发现有宫内妊娠。
