Pride Veterinary Centre, Derby, DE24 8HX, UK.
Departament de Medicina i Cirurgia Animals, and Fundació Hospital Clínic Veterinari, Autonomous University of Barcelona, College of Veterinary Medicine, Barcelona, 08193, Spain.
J Small Anim Pract. 2022 Jun;63(6):486-491. doi: 10.1111/jsap.13451. Epub 2021 Dec 15.
Malignant pulmonary neoplasia associated with cystic airspaces is a well-recognised disease entity in humans. Two elderly dogs, previously diagnosed with a solitary emphysematous bulla, presented with non-specific clinical signs. At presentation, pulmonary auscultation was unremarkable. In both cases, thoracic CT demonstrated the transformation of the cystic airspace lesions characterised by a progressive increase of the solid component and reduction of the air component. Cytological evaluation and subsequent surgical excision followed by histopathology confirmed pulmonary carcinoma in both cases. These two cases represent the first demonstration of possible malignant transformation of pulmonary cystic airspace in dogs. Veterinarians should consider neoplastic transformation as a differential diagnosis in cases of cystic airspaces, particularly cases with features including thickening or irregularity of the wall, associated soft-tissue nodules or solid and non-solid tissue intermixed within clusters of multiple cystic airspaces. Ongoing monitoring of cystic airspace lesions through diagnostic imaging is recommended.
与人相关的伴囊状气腔恶性肺肿瘤是一种被广泛认知的疾病实体。两只老年犬，先前被诊断为孤立性气肿性大疱，表现出非特异性的临床症状。就诊时，肺部听诊无明显异常。在这两种情况下，胸部 CT 显示囊状气腔病变发生了变化，其特征为实性成分逐渐增加，空气成分减少。细胞学评估和随后的手术切除以及组织病理学检查在这两种情况下均证实为肺腺癌。这两个病例代表了犬类肺囊状气腔可能发生恶性转化的首例证明。兽医应将肿瘤性转化作为囊状气腔的鉴别诊断之一，特别是具有以下特征的病例：囊壁增厚或不规则、伴有软组织结节或多个囊状气腔簇内的实性和非实性组织混合。建议通过诊断性影像学对囊状气腔病变进行持续监测。
