Institute of Pesticide and Environmental Toxicology, the Key Laboratory of Molecular Biology of Crop Pathogens and Insects, College of Agricultural and Biotechnology, Zhejiang University, Hangzhou 310058, China.
The Laboratory for Phytochemistry and Plant-derived Pesticides, College of Agriculture, Jiangxi Agricultural University, Nanchang 330045, China.
J Agric Food Chem. 2021 Dec 29;69(51):15538-15543. doi: 10.1021/acs.jafc.1c05396. Epub 2021 Dec 17.
As a global health problem, the source of triazole resistance in has gained much attention. This study was conducted to explore whether the triazole plant regulator paclobutrazol could evolve triazole resistance in . The results indicated that two triazole-resistant strains with hereditary stability were isolated from liquid medium and soil. The up-regulation of , , , , , , and played an important role in these resistant strains. The triazole-resistance in could depend on the selective pressure of paclobutrazol concentration and exposure time. These results indicate that the application of paclobutrazol may result in the emergency of triazole resistance in and thus have a potential risk for the treatment of invasive aspergillosis.
作为一个全球性的健康问题， 中三唑类耐药性的来源引起了广泛关注。本研究旨在探讨三唑类植物生长调节剂多效唑是否会导致 中三唑类耐药性的产生。结果表明，从液体培养基和土壤中分离到了具有遗传稳定性的两株三唑类耐药菌株。 、 、 、 、 、 和 的上调在这些耐药菌株中发挥了重要作用。 中三唑类耐药性可能取决于多效唑浓度和暴露时间的选择压力。这些结果表明，多效唑的应用可能导致 中三唑类耐药性的出现，从而对侵袭性曲霉菌病的治疗构成潜在风险。
