α7 型烟碱型乙酰胆碱受体在海马回路中的作用：驯服复杂性。
α7 nicotinic acetylcholine receptors in the hippocampal circuit: taming complexity.
机构信息
Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, P.O. Box 12233, Durham, NC 27709, USA.
Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, P.O. Box 12233, Durham, NC 27709, USA.
出版信息
Trends Neurosci. 2022 Feb;45(2):145-157. doi: 10.1016/j.tins.2021.11.006. Epub 2021 Dec 13.
Abstract
Cholinergic innervation of the hippocampus uses the neurotransmitter acetylcholine (ACh) to coordinate neuronal circuit activity while simultaneously influencing the function of non-neuronal cell types. The α7 nicotinic ACh receptor (nAChR) subtype is highly expressed throughout the hippocampus, has the highest calcium permeability compared with other subtypes of nAChRs, and is of high therapeutic interest due to its association with a variety of neurological disorders and neurodegenerative diseases. In this review, we synthesize research describing α7 nAChR properties, function, and relationship to cognitive dysfunction within the hippocampal circuit and highlight approaches to help improve therapeutic development.
摘要
海马体的胆碱能神经支配使用神经递质乙酰胆碱 (ACh) 来协调神经元回路活动，同时影响非神经元细胞类型的功能。α7 烟碱型乙酰胆碱受体 (nAChR) 亚型在整个海马体中高度表达，与其他 nAChR 亚型相比具有最高的钙通透性，并且由于其与多种神经紊乱和神经退行性疾病有关，因此具有很高的治疗价值。在这篇综述中，我们综合了描述 α7 nAChR 特性、功能以及与海马体回路认知功能障碍之间关系的研究，并强调了有助于改善治疗开发的方法。
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