肿瘤免疫学中一些形式模型的综述。
A survey of some formal models in tumor immunology.
作者信息
Dullens H F, Van der Tol M W, De Weger R A, Den Otter W
出版信息
Cancer Immunol Immunother. 1986;23(3):159-64. doi: 10.1007/BF00205644.
Computer technology has acquired an important role in structuring a variety of biological systems. The availability of modern powerful computers has stimulated the development of good and accurate models of biological systems. Biological systems, such as the immune response against cancer, are complex and it is difficult to experimentally control all the interacting elements constituting the immune response of a host to cancer. Complex biosystems do not always behave or act as expected during experimental investigation. In these cases computer models can be helpful in understanding the behavior of such complex systems. The purpose of this review is to consider the use of mathematical models to study the immune response against cancer. The logic and design of some operable models relevant for tumor immunology will be discussed. Special attention is given to the conceptualization of a model based upon a new hypothesis of tumor rejection presented by De Weger et al. [10]. Technical details concerning the mathematical aspects, differential equations, details on hardware and software package etc. are not included in this survey. These details are contained to in the original papers.
计算机技术在构建各种生物系统中发挥了重要作用。现代强大计算机的可用性推动了生物系统良好且准确模型的发展。生物系统，如针对癌症的免疫反应，是复杂的，很难通过实验控制构成宿主对癌症免疫反应的所有相互作用元素。在实验研究期间，复杂生物系统的行为并不总是如预期那样。在这些情况下，计算机模型有助于理解此类复杂系统的行为。本综述的目的是探讨使用数学模型来研究针对癌症的免疫反应。将讨论一些与肿瘤免疫学相关的可操作模型的逻辑和设计。特别关注基于De Weger等人[10]提出的肿瘤排斥新假说的模型概念化。本综述不包括有关数学方面、微分方程、硬件和软件包等的技术细节。这些细节包含在原始论文中。
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