高IgE综合征循环免疫复合物中的IgG抗IgE

IgG anti-IgE in circulating immune complexes in the hyper-IgE syndrome.

作者信息

Paganelli R, Quinti I, Carbonari M, Pontesilli O, D'Offizi G P, Letta T, Aiuti F

出版信息

Clin Allergy. 1986 Nov;16(6):513-21. doi: 10.1111/j.1365-2222.1986.tb01989.x.

DOI:10.1111/j.1365-2222.1986.tb01989.x

Abstract

We fractionated, by gel chromatography, sera with high IgE content from atopic subjects and five cases with the hyper-IgE syndrome, and measured the presence of IgE in high molecular weight (HMW) fractions. Two out of four asthmatics and four out of five hyper-IgE had HMW IgE. The same serum fractions gave positive results for conglutinin binding IgG (all six) and IgA (three cases) as well as C1q binding complexes (five cases). IgG auto-antibodies to IgE were also detected together with IgE in HMW fractions. Anti-F(ab)'2 activity was present in five cases (one of them negative for IgG anti-IgE). Our data indicate that complexes made of IgE and IgG anti-IgE are present mainly in patients with chronic allergic symptoms and most frequent in cases of hyper-IgE syndrome.

摘要

我们通过凝胶色谱法对特应性个体和5例高IgE综合征患者的高IgE含量血清进行分级分离，并检测高分子量（HMW）级分中IgE的存在情况。4例哮喘患者中有2例以及5例高IgE患者中有4例存在HMW IgE。相同的血清级分对胶固素结合IgG（全部6例）和IgA（3例）以及C1q结合复合物（5例）检测呈阳性结果。在HMW级分中还检测到了IgG抗IgE自身抗体以及IgE。5例存在抗F(ab)'2活性（其中1例IgG抗IgE检测为阴性）。我们的数据表明，由IgE和IgG抗IgE组成的复合物主要存在于慢性过敏症状患者中，在高IgE综合征患者中最为常见。