Rerat Solene, Amsellem-Jager Jessica, L'hour Marie Clemence, Bouhours-Nouet Natacha, Donzeau Aurelie, Rouleau Stephanie, Levaillant Lucie, Emeriau Fabienne, Moal Valerie, Boux de Casson Florence, Lahlou Najiba, Coutant Regis
Department of Pediatric Endocrinology, University Hospital, 49000 Angers, France.
Reference Center for Rare Pituitary Diseases, University Hospital, 49000 Angers, France.
J Clin Endocrinol Metab. 2022 Mar 24;107(4):e1568-e1576. doi: 10.1210/clinem/dgab845.
Alterations in semen characteristics and circulating Sertoli and Leydig cell hormones have been described in obese male adults. Whether hormonal alterations occur before adulthood has not been fully evaluated.
We describe circulating Sertoli and Leydig cell hormone levels in overweight-obese (ow/ob) boys through childhood and adolescence in a cross-sectional study.
Monocentric study in the Pediatric Endocrinology Unit of Angers University Hospital. Three hundred and fifty-one obese and overweight boys aged 5-19 years underwent physical examination, dual-energy X-ray absorptiometry for body composition, oral glucose tolerance test on insulin and glucose, and measurements of follicle-stimulating hormone, luteinizing hormone, anti-Müllerian hormone (AMH), inhibin B, testosterone, and estradiol. Hormonal levels were compared with normative data obtained from 652 healthy nonoverweight nonobese boys of similar age or Tanner stage.
Median inhibin B and testosterone levels during puberty were significantly lower in ow/ob than in healthy boys (1) from age >12 years and thereafter for inhibin B, and (2) from age >14 years and thereafter for testosterone. At Tanner stages 4 and 5, 26%, 31%, and 18% of inhibin B, testosterone, and AMH values were below the 5th percentile in ow/ob subjects (P < .01). In multiple regression analyses, estradiol and total bone mineral density Z-score were negative predictors of inhibin B, fat mass percentage was a negative predictor of testosterone, and insulin was a negative predictor of AMH.
Lower Sertoli and Leydig cell hormone levels during puberty were observed in the ow/ob boys.
肥胖成年男性的精液特征以及支持细胞和间质细胞激素水平的变化已有相关描述。但激素变化是否在成年前就已发生尚未得到充分评估。
在一项横断面研究中，我们描述了超重肥胖（ow/ob）男孩在儿童期和青春期的支持细胞和间质细胞激素循环水平。
在昂热大学医院儿科内分泌科进行的单中心研究。351名年龄在5 - 19岁的肥胖和超重男孩接受了体格检查、双能X线吸收法测量身体成分、口服葡萄糖耐量试验检测胰岛素和葡萄糖水平，以及测量促卵泡激素、促黄体生成素、抗苗勒管激素（AMH）、抑制素B、睾酮和雌二醇。将这些激素水平与从652名年龄或坦纳分期相似的健康非超重非肥胖男孩获得的标准数据进行比较。
（1）对于抑制素B，ow/ob男孩青春期期间的抑制素B和睾酮水平中位数显著低于健康男孩，从年龄>12岁及之后开始；（②）对于睾酮，从年龄>14岁及之后开始。在坦纳分期4和5时，ow/ob受试者中26%、31%和18%的抑制素B、睾酮和AMH值低于第5百分位数（P < 0.01）。在多元回归分析中，雌二醇和总骨矿物质密度Z评分是抑制素B的负预测因子，脂肪质量百分比是睾酮的负预测因子，胰岛素是AMH的负预测因子。
在ow/ob男孩中观察到青春期期间支持细胞和间质细胞激素水平较低。
