24,25(OH)₂D₃增强了1,25(OH)₂D₃对甲状旁腺切除大鼠的血钙升高作用。

24,25(OH)2D3 enhances the calcemic effect of 1,25(OH)2D3 in PTX rats.

作者信息

Wald H, Traves J, Popovtzer M M

出版信息

Proc Soc Exp Biol Med. 1987 Jan;184(1):47-9. doi: 10.3181/00379727-184-42444.

PMID:3491995

Abstract

The effect of 24,25(OH)2D3 on 1,25(OH)2D3-induced hypercalcemia was studied in parathyroidectomized (PTX) rats for 10 days. Serum (S) and urinary Ca excretion (UCaV) were measured in (a) control rats, (b) rats receiving a daily sc injection of 54 ng 1,25(OH)2D3, (c) rats receiving 24,25(OH)2D3 in the same dose and same manner, and (d) rats receiving 1,25(OH)2D3 + 24,25(OH)2D3. Our results show that (i) 24,25(OH)2D3 alone does not increase SCa2+ in PTX rats, (ii) combined administration of 1,25(OH)2D3 + 24,25(OH)2D3 enhances the hypercalcemic response to 1,25(OH)2D3 without a parallel increase in UCaV, (iii) combined administration of 1,25(OH)2D3 + 24,25(OH)2D3 reduces the rise in urinary excretion of Ca2+ compared with that of rats receiving 1,25(OH)2D3 alone for 10 days, and (iv) these alterations are independent of parathyroid hormone.

摘要

在甲状旁腺切除（PTX）的大鼠中研究了24,25（OH）2D3对1,25（OH）2D3诱导的高钙血症的影响，为期10天。对以下几组大鼠测量了血清（S）和尿钙排泄量（UCaV）：（a）对照大鼠；（b）每天皮下注射54 ng 1,25（OH）2D3的大鼠；（c）以相同剂量和相同方式接受24,25（OH）2D3的大鼠；（d）接受1,25（OH）2D3 + 24,25（OH）2D3的大鼠。我们的结果表明：（i）单独使用24,25（OH）2D3不会增加PTX大鼠的血清钙（SCa2+）；（ii）联合给予1,25（OH）2D3 + 24,25（OH）2D3可增强对1,25（OH）2D3的高钙血症反应，而尿钙排泄量（UCaV）不会相应增加；（iii）与单独接受1,25（OH）2D3 10天的大鼠相比，联合给予1,25（OH）2D3 + 24,25（OH）2D3可降低尿钙（Ca2+）排泄量的升高；（iv）这些改变与甲状旁腺激素无关。