Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, SE5 9RS, United Kingdom.
Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, SE5 9RS, United Kingdom; Asthma UK Centre for Allergic Mechanisms in Asthma, King's College London, SE1 9RT, United Kingdom; National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London, SE1 9RT, United Kingdom.
Early Hum Dev. 2022 Jan;164:105523. doi: 10.1016/j.earlhumdev.2021.105523. Epub 2021 Dec 13.
Carboxyhaemoglobin (COHb) levels may reflect the level of early oxidative stress which plays a role in mediating free-radical-related diseases in prematurely born infants.
To assess the relationship of COHb levels in the first seven days of after birth to the development of bronchopulmonary dysplasia (BPD) and other free-radical-related diseases.
Retrospective analysis of routinely performed COHb via blood gas samples of infants born at less than 30 weeks of gestation admitted to a tertiary neonatal intensive care unit was undertaken.
One hundred and four infants were included with a median (range) gestational age of 27.4 (22.4-29.9) weeks and a birthweight of 865 (395-1710) grams.
The maximum COHb per infant per day was recorded for the first 28 days and BPD and other free-radical-related diseases including intraventricular haemorrhage (IVH) were noted. The severity of BPD, requirement for home oxygen on discharge and survival to discharge were also recorded.
Infants who developed BPD (n = 76) had significantly higher COHb levels in the first seven days [1.7% (0.3-6.8)] compared to those that did not develop BPD [1.6% (0.9-3.8); p = 0.001]. Higher COHb levels in the first seven days after birth were also observed in infants with grade three/four IVH [n = 20; 1.9% (1.0-6.8)] compared to those without [1.6% (0.3-5.6); p < 0.001]. COHb levels, however, were not associated with the duration of ventilation, BPD severity or survival to discharge.
Higher COHb levels in prematurely born infants were associated with the development of BPD and IVH.
碳氧血红蛋白（COHb）水平可能反映早期氧化应激的水平，氧化应激在介导早产儿自由基相关疾病中起作用。
评估出生后 7 天内 COHb 水平与支气管肺发育不良（BPD）和其他自由基相关疾病的发展之间的关系。
对入住三级新生儿重症监护病房的胎龄小于 30 周的早产儿进行常规血气样本 COHb 的回顾性分析。
104 例婴儿，中位（范围）胎龄为 27.4（22.4-29.9）周，出生体重为 865（395-1710）克。
记录了每名婴儿在第 1 至 28 天内每天的最大 COHb 值，并记录了 BPD 和其他自由基相关疾病，包括脑室内出血（IVH）。还记录了 BPD 的严重程度、出院时对家庭氧气的需求以及出院时的存活率。
出生后 7 天内 COHb 水平较高的早产儿发生 BPD 和 IVH 的风险增加。
