Department of Neurosurgery, University of Utah, Salt Lake City, UT, USA.
Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA.
Sci Rep. 2021 Dec 17;11(1):24155. doi: 10.1038/s41598-021-03414-5.
In this study, we quantified the coverage of gray and white matter during intracranial electroencephalography in a cohort of epilepsy patients with surface and depth electrodes. We included 65 patients with strip electrodes (n = 12), strip and grid electrodes (n = 24), strip, grid, and depth electrodes (n = 7), or depth electrodes only (n = 22). Patient-specific imaging was used to generate probabilistic gray and white matter maps and atlas segmentations. Gray and white matter coverage was quantified using spherical volumes centered on electrode centroids, with radii ranging from 1 to 15 mm, along with detailed finite element models of local electric fields. Gray matter coverage was highly dependent on the chosen radius of influence (RoI). Using a 2.5 mm RoI, depth electrodes covered more gray matter than surface electrodes; however, surface electrodes covered more gray matter at RoI larger than 4 mm. White matter coverage and amygdala and hippocampal coverage was greatest for depth electrodes at all RoIs. This study provides the first probabilistic analysis to quantify coverage for different intracranial recording configurations. Depth electrodes offer increased coverage of gray matter over other recording strategies if the desired signals are local, while subdural grids and strips sample more gray matter if the desired signals are diffuse.
在这项研究中，我们对有表面和深部电极的癫痫患者队列进行了颅内脑电图的灰质和白质覆盖率的量化研究。我们纳入了 65 例患者，其中使用条带电极（n=12）、条带和网格电极（n=24）、条带、网格和深部电极（n=7）或仅深部电极（n=22）。患者特异性成像用于生成概率灰质和白质图谱和图谱分割。使用以电极质心为中心的球形体积，半径为 1 至 15 毫米，结合局部电场的详细有限元模型，对灰质和白质覆盖率进行量化。灰质覆盖率高度依赖于所选影响半径（RoI）。使用 2.5 毫米的 RoI，深部电极比表面电极覆盖更多的灰质；然而，在 RoI 大于 4 毫米时，表面电极覆盖更多的灰质。在所有 RoI 中，深部电极的白质覆盖率以及杏仁核和海马体的覆盖率最大。这项研究提供了第一个概率分析，以量化不同颅内记录配置的覆盖范围。如果所需信号是局部的，深部电极提供了比其他记录策略更多的灰质覆盖范围，而如果所需信号是弥散的，则硬膜下网格和条带可以采集更多的灰质。
