Department of Obstetrics and Gynecology McMaster University, Division of Maternal Fetal Medicine, Hamilton, ON; Department of Obstetrics and Gynecology University of Saskatchewan, Regina General Hospital, Regina, SK.
Department of Obstetrics and Gynecology McMaster University, Division of Maternal Fetal Medicine, Hamilton, ON.
J Obstet Gynaecol Can. 2022 Apr;44(4):390-394.e3. doi: 10.1016/j.jogc.2021.11.017. Epub 2021 Dec 16.
Vitamin B deficiency has been linked to neurocognitive symptoms. Vitamin B deficiency in pregnancy may be associated with antenatal or postpartum depression along with other neurocognitive symptoms including restless leg syndrome. The objective of this study was to systematically review the literature regarding vitamin B deficiency and insufficiency in pregnancy and its effects on maternal neurocognitive symptoms.
MEDLINE, Embase, and SCOPUS were searched from inception to October, 2020.
Observational studies and randomized controlled trials of singleton pregnancies involving vitamin B deficiency and reporting maternal neurocognitive outcomes were identified.
Data were synthesized and are presented narratively.
The 5 studies included in the analysis did not demonstrate a statistically significant link between vitamin B deficiency or insufficiency and either restless leg syndrome or depression in pregnancy. To date, evidence is lacking that would support a causal link between suboptimal vitamin B serum levels and maternal restless leg syndrome or depression.
维生素 B 缺乏与神经认知症状有关。孕妇维生素 B 缺乏可能与产前或产后抑郁以及其他神经认知症状（包括不宁腿综合征）有关。本研究的目的是系统回顾有关妊娠期间维生素 B 缺乏和不足及其对产妇神经认知症状影响的文献。
从建库到 2020 年 10 月，检索了 MEDLINE、Embase 和 SCOPUS 数据库。
确定了涉及维生素 B 缺乏症并报告产妇神经认知结局的单胎妊娠的观察性研究和随机对照试验。
综合数据并以叙述方式呈现。
分析中纳入的 5 项研究并未显示维生素 B 缺乏或不足与妊娠期间不宁腿综合征或抑郁之间存在统计学显著关联。迄今为止，缺乏证据支持血清维生素 B 水平不理想与产妇不宁腿综合征或抑郁之间存在因果关系。
