病毒-宿主蛋白相互作用是人类巨细胞病毒复制的痕迹。
Virus-host protein interactions as footprints of human cytomegalovirus replication.
机构信息
Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Washington Road, Princeton, NJ 08544, USA.
Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Washington Road, Princeton, NJ 08544, USA.
出版信息
Curr Opin Virol. 2022 Feb;52:135-147. doi: 10.1016/j.coviro.2021.11.016. Epub 2021 Dec 16.
Abstract
Human cytomegalovirus (HCMV) is a pervasive β-herpesvirus that causes lifelong infection. The lytic replication cycle of HCMV is characterized by global organelle remodeling and dynamic virus-host interactions, both of which are necessary for productive HCMV replication. With the advent of new technologies for investigating protein-protein and protein-nucleic acid interactions, numerous critical interfaces between HCMV and host cells have been identified. Here, we review temporal and spatial virus-host interactions that support different stages of the HCMV replication cycle. Understanding how HCMV interacts with host cells during entry, replication, and assembly, as well as how it interfaces with host cell metabolism and immune responses promises to illuminate processes that underlie the biology of infection and the resulting pathologies.
摘要
人巨细胞病毒（HCMV）是一种普遍存在的β疱疹病毒，可导致终身感染。HCMV 的裂解复制周期的特点是全局细胞器重塑和动态的病毒-宿主相互作用，这两者都是有效的 HCMV 复制所必需的。随着研究蛋白质-蛋白质和蛋白质-核酸相互作用的新技术的出现，已经确定了 HCMV 与宿主细胞之间的许多关键界面。在这里，我们回顾了支持 HCMV 复制周期不同阶段的时空病毒-宿主相互作用。了解 HCMV 在进入、复制和组装过程中与宿主细胞相互作用的方式，以及它与宿主细胞代谢和免疫反应的接口，有望阐明感染生物学和由此产生的病理的基础过程。
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