Yamagata University Graduate School of Medical Science, Yamagata, Japan.
Department of Home Nursing, Yamagata University Graduate School of Medical Science, Yamagata, Japan.
Ann Nutr Metab. 2022;78(2):91-97. doi: 10.1159/000521536. Epub 2021 Dec 17.
Serum albumin (Alb) levels have been found to be independent predictors of all-cause mortality in a community-based population, but whether this is the case for serum cholinesterase (ChE) levels is uncertain. This study aimed to determine whether serum ChE levels are independent predictors of all-cause mortality in a community-based population.
A total of 3,504 subjects (mean age 62.5 years) from Takahata, Japan, participated and were followed up for 13.5 years (median 13.2 years). Based on baseline serum Alb and ChE levels, subjects were stratified by interquartile range as low, middle, and high. The correlation between serum Alb and ChE levels was examined by calculating correlation coefficients. The association between each group and all-cause mortality was examined by Kaplan-Meier and Cox proportional hazards analyses.
During follow-up, 568 subjects died. There was a positive correlation between serum Alb and ChE levels (r = 0.30). Kaplan-Meier analysis showed that all-cause mortality in the low group was significantly higher for both serum Alb and ChE levels (log-rank p < 0.01). Adjusted Cox proportional hazards analysis showed that the serum Alb level was not an independent predictor of all-cause mortality (hazard ratio [HR] 1.18, 95% confidence interval [CI], 0.95-1.46 for all-cause mortality in the low group compared to the middle group), whereas the serum ChE level was an independent predictor of all-cause mortality (HR 1.30, 95% CI, 1.06-1.59 for all-cause mortality in the low group compared to the middle group).
The serum ChE level is an independent predictor of all-cause mortality in the general community-based population.
在社区人群中，血清白蛋白（Alb）水平被发现是全因死亡率的独立预测因素，但血清胆碱酯酶（ChE）水平是否如此尚不确定。本研究旨在确定血清 ChE 水平是否是社区人群全因死亡率的独立预测因素。
本研究共纳入日本高畠町 3504 名受试者（平均年龄 62.5 岁），随访 13.5 年（中位数 13.2 年）。根据基线血清 Alb 和 ChE 水平，按四分位间距将受试者分为低、中、高 3 组。通过计算相关系数来检查血清 Alb 和 ChE 水平之间的相关性。通过 Kaplan-Meier 和 Cox 比例风险分析来检查每组与全因死亡率的关系。
在随访期间，有 568 名受试者死亡。血清 Alb 和 ChE 水平之间存在正相关（r=0.30）。Kaplan-Meier 分析显示，低 Alb 和低 ChE 水平组的全因死亡率均显著升高（对数秩检验 p<0.01）。调整后的 Cox 比例风险分析显示，血清 Alb 水平不是全因死亡率的独立预测因素（低 Alb 水平组与中 Alb 水平组相比，全因死亡率的危险比[HR]为 1.18，95%置信区间[CI]为 0.95-1.46），而血清 ChE 水平是全因死亡率的独立预测因素（低 Alb 水平组与中 Alb 水平组相比，全因死亡率的 HR 为 1.30，95%CI 为 1.06-1.59）。
在一般社区人群中，血清 ChE 水平是全因死亡率的独立预测因素。
