School of Kinesiology, Faculty of Medicine, Universidad Finis Terrae, Santiago, Chile.
Centro de Salud Deportiva. Clínica Santa María, Santiago, Chile.
Curr Med Chem. 2022;29(6):1110-1123. doi: 10.2174/0929867329666211217100020.
Loss of skeletal muscle (SkM) quality is associated with different clinical conditions such as aging, diabetes, obesity, cancer, and heart failure. Nutritional research has focused on identifying naturally occurring molecules that mitigate the loss of SkM quality induced by pathology or syndrome. In this context, although few human studies have been conducted, epicatechin (Epi) is a prime candidate that may positively affect SkM quality by its potential ability to mitigate muscle mass loss. This seems to be a consequence of its antioxidant and anti-inflammatory properties and its stimulation of mitochondrial biogenesis to increase myogenic differentiation, as well as its modulation of key proteins involved in SkM structure, function, metabolism, and growth. In conclusion, the Epi could prevent, mitigate, delay, and even treat muscle-related disorders caused by aging and diseases. However, studies in humans are needed.
骨骼肌（SkM）质量的丧失与多种临床情况相关，如衰老、糖尿病、肥胖、癌症和心力衰竭。营养研究的重点是确定天然存在的分子，以减轻由病理或综合征引起的 SkM 质量损失。在这种情况下，尽管进行了少量的人体研究，但表儿茶素（Epi）是一个主要的候选者，它可能通过其减轻肌肉质量损失的潜在能力，对 SkM 质量产生积极影响。这似乎是由于其抗氧化和抗炎特性以及刺激线粒体生物发生以增加成肌分化，以及调节参与 SkM 结构、功能、代谢和生长的关键蛋白质的结果。总之，Epi 可以预防、减轻、延迟，甚至治疗由衰老和疾病引起的与肌肉相关的疾病。然而，需要在人类中进行研究。
