Kudo Moeko, Wupuer Sidikejiang, Kubota Shinji, Seki Kazuhiko
Department of Neurophysiology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.
Front Syst Neurosci. 2021 Dec 2;15:801492. doi: 10.3389/fnsys.2021.801492. eCollection 2021.
The aim of this study was to elucidate the size and distribution of dorsal root ganglion (DRG) neurons in non-human primates and to compare them with those of rodent DRG neurons. By measuring the size of NeuN-, NF200-, and peripherin-positive DRG neurons in the lumbar spinal cord of rats and marmosets, we found that the cell size distribution pattern was comparable in both species, although DRG neurons in marmosets were larger than those of rodents. This is the first demonstration that DRG neurons in marmosets have a bimodal size distribution, which has been well established in rodents and humans.
本研究的目的是阐明非人灵长类动物背根神经节(DRG)神经元的大小和分布,并将其与啮齿动物的DRG神经元进行比较。通过测量大鼠和狨猴腰脊髓中NeuN、NF200和外周蛋白阳性DRG神经元的大小,我们发现尽管狨猴的DRG神经元比啮齿动物的大,但两种物种的细胞大小分布模式具有可比性。这是首次证明狨猴的DRG神经元具有双峰大小分布,这在啮齿动物和人类中已得到充分证实。