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在常规临床实践中,患者报告的浴强直性脊柱炎疾病活动指数(BASDAI)评分与轴性脊柱关节炎的MRI表现之间是否存在相关性?

Is There a Correlation Between Patient-Reported Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) Score and MRI Findings in Axial Spondyloarthropathy in Routine Clinical Practice?

作者信息

Byravan Swetha, Jain Nibha, Stairs Jenna, Rennie Winston, Moorthy Arumugam

机构信息

Rheuamtology, University Hospitals of Leicester National Health Service Trust, Leicester, GBR.

Rheumatology, University Hospitals of Leicester National Health Service Trust, Leicester, GBR.

出版信息

Cureus. 2021 Nov 16;13(11):e19626. doi: 10.7759/cureus.19626. eCollection 2021 Nov.

Abstract

Background The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) is the patient-reported outcome (PRO) that is routinely used in clinical practice to monitor and measure disease activity in axial spondyloarthropathy (axSpA). BASDAI scores greater than four are thought to indicate active disease and require better control. Magnetic resonance imaging (MRI) is the most objective measure of disease activity in axSpA with its ability to pick up active inflammation both in the spine and sacroiliac joints. Previous studies have shown conflicting correlations between BASDAI and MRI, and therefore, there is the question of whether BASDAI is the best tool to monitor disease activity when it is subjective and potentially influenced by other patient factors. We, therefore, conducted a retrospective study to investigate the correlation between BASDAI and MRI in axSpA patients. Methodology Data were collected by retrospective analysis of axSpA patients attending University of Leicester (UHL) axSpA services. BASDAI scores were done within a year and closest to the time of MRI spine + sacroiliac joints were collected. The results prior to the initiation of biologic therapy were used. Data of one hundred and forty-nine patients were collected on their MRI results and BASDAI scores. Data were analysed using Statistical Package for the Social Sciences (SPSS) software and Pearson's chi-squared applied to assess the correlation between BASDAI and MRI findings. Results Out of one hundred and forty-nine patients, 61.7% had active sacroiliitis on their MRI, 57.7% had chronic sacroiliitis, 53% had active spinal inflammation, and 17.4% had other MRI findings of active disease. There was a significant correlation between active sacroiliitis and BASDAI (p=0.014), but similar results were not found with other radiological features. A significant correlation was also found with males having higher BASDAI scores compared to females (p=0.027). Conclusion This study demonstrates a statistically significant correlation between BASDAI and active sacroiliitis with those having higher scores more likely to have active disease on their MRI.

摘要

背景

巴斯强直性脊柱炎疾病活动指数(BASDAI)是一种患者报告结局(PRO),在临床实践中常用于监测和衡量轴性脊柱关节炎(axSpA)的疾病活动度。BASDAI评分大于4被认为提示疾病活动,需要更好的控制。磁共振成像(MRI)是评估axSpA疾病活动度最客观的方法,它能够发现脊柱和骶髂关节的活动性炎症。既往研究显示BASDAI与MRI之间的相关性存在矛盾,因此,当BASDAI具有主观性且可能受其他患者因素影响时,它是否是监测疾病活动度的最佳工具存在疑问。因此,我们进行了一项回顾性研究,以调查axSpA患者中BASDAI与MRI之间的相关性。

方法

通过对莱斯特大学(UHL)axSpA门诊患者的回顾性分析收集数据。BASDAI评分在一年内完成,且最接近采集脊柱+骶髂关节MRI的时间。使用生物治疗开始前的结果。收集了149例患者的MRI结果和BASDAI评分数据。使用社会科学统计软件包(SPSS)软件进行数据分析,并应用Pearson卡方检验评估BASDAI与MRI结果之间的相关性。

结果

149例患者中,61.7%的患者MRI显示骶髂关节炎活动,57.7%为慢性骶髂关节炎,53%有脊柱活动性炎症,17.4%有其他疾病活动的MRI表现。骶髂关节炎活动与BASDAI之间存在显著相关性(p=0.014),但其他影像学特征未发现类似结果。还发现男性BASDAI评分高于女性(p=0.027)。

结论

本研究表明BASDAI与骶髂关节炎活动之间存在统计学显著相关性,评分较高者MRI上更可能有疾病活动。

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