Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, China.
Department of Chemistry, Fudan University, Shanghai, 200433, China.
Small Methods. 2021 Dec;5(12):e2100969. doi: 10.1002/smtd.202100969. Epub 2021 Nov 16.
Manipulating droplets by light in microscale allows precise control of microfluidics, liquid delivery, micromachines, and so on. Among these applications, microfluidic technology is of particular interest for miniaturization of the portable analysis systems, which require the integration of various liquid operations in one device. Here, a photodeformable microfluidic platform is constructed by combining Laplace pressure and capillary condensation to integrate the transportation, fusion, separation, and mixing of liquid slugs in one chip. The Laplace pressure, attributed to the photodeformation of the liquid crystal polymers, is generated to propel the slug. The capillary condensation is introduced by the delicate design of the fluid channels, allowing the fusion and separation of slugs without any connected microvalves. Catalytic oxidation reaction and protein detection processes are realized in the platform, which are amenable to a variety of miniaturized bio-medical applications, such as portable analysis and point of care testing.
通过微尺度光来操控液滴，可以实现对微流控、液体输送、微机械等的精确控制。在这些应用中，微流控技术对于便携式分析系统的小型化特别有吸引力，因为这种系统需要在一个设备中集成各种液体操作。在这里，通过结合拉普拉斯压力和毛细凝结作用，构建了一个光可变形微流控平台，以在一个芯片中集成液体弹丸的输送、融合、分离和混合。液滴的推进是通过液晶聚合物的光变形产生的拉普拉斯压力实现的。毛细凝结是通过对流体通道的精细设计引入的，允许弹丸的融合和分离，而无需任何连接的微阀。在该平台上实现了催化氧化反应和蛋白质检测过程，适用于各种小型化的生物医学应用，如便携式分析和即时检测。
