Yeung Helen H, Kumar-Singh Rajendra, Walton David S
J Pediatr Ophthalmol Strabismus. 2022 Jul-Aug;59(4):236-242. doi: 10.3928/01913913-20210929-02. Epub 2021 Dec 20.
To review information pertaining to secondary glaucoma following infant lensectomy and provide evidence to support the mechanism responsible for this condition.
Reported risk factors and proposed mechanisms for infantile aphakic glaucoma are reviewed. Laboratory studies and clinical observations in affected patients with glaucoma are described. Evidence of postoperative anterior chamber fibrosis is reviewed and interpreted.
Clinical evidence demonstrated the development of anterior chamber fibrosis following infant cataract surgery. Laboratory studies showed liberated lens epithelial cell transition to fibroblasts.
The review and assessment of laboratory and clinical evidence support the proposal that infantile aphakic glaucoma is caused, in part, by postoperative anterior chamber fibroization related to lens cell dispersion, cytokine activation, and epithelial-mesenchymal transition with resultant filtration angle fibrosis and secondary loss of filtration function. .
回顾与婴儿晶状体切除术后继发性青光眼相关的信息，并提供证据支持导致这种情况的机制。
回顾报道的婴儿无晶状体性青光眼的危险因素和提出的机制。描述青光眼患者的实验室研究和临床观察。回顾并解释术后前房纤维化的证据。
临床证据表明婴儿白内障手术后前房纤维化的发展。实验室研究显示释放的晶状体上皮细胞转变为成纤维细胞。
对实验室和临床证据的回顾与评估支持以下观点，即婴儿无晶状体性青光眼部分是由与晶状体细胞分散、细胞因子激活以及上皮-间质转化相关的术后前房纤维化引起的，导致滤过角纤维化和滤过功能继发性丧失。
