与异维A酸胚胎病相关的胸腺发育不全。

Thymic hypoplasia associated with isotretinoin embryopathy.

作者信息

Cohen M, Rubinstein A, Li J K, Nathenson G

出版信息

Am J Dis Child. 1987 Mar;141(3):263-6. doi: 10.1001/archpedi.1987.04460030041020.

DOI:10.1001/archpedi.1987.04460030041020

Abstract

A newborn had isotretinoin embryopathy, including thymic hypoplasia. Evaluation of her immune functions demonstrated progressive attrition of T cells over the nine weeks until her death due to pneumonia. These studies strongly suggest an insult by isotretinoin to the immune system. Immune abnormalities may predispose infants with isotretinoin embryopathy to infection and contribute to their high mortality.

摘要

一名新生儿患有异维甲酸胚胎病，包括胸腺发育不全。对其免疫功能的评估显示，在直至她因肺炎死亡的九周时间里，T细胞逐渐减少。这些研究有力地表明异维甲酸对免疫系统造成了损害。免疫异常可能使患有异维甲酸胚胎病的婴儿易受感染，并导致其高死亡率。