Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.
Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.
Free Radic Biol Med. 2022 Feb 1;179:11-23. doi: 10.1016/j.freeradbiomed.2021.12.264. Epub 2021 Dec 17.
Mitochondrion is the powerhouse of the cell. The research of nearly a century has expanded our understanding of mitochondrion, far beyond the view that mitochondrion is an important energy generator of cells. During the initiation, growth and survival of tumor cells, significant mitochondrial metabolic changes have taken place in the important enzymes of respiratory chain and tricarboxylic acid cycle, mitochondrial biogenesis and dynamics, oxidative stress regulation and molecular signaling. Therefore, mitochondrial metabolic proteins are the key mediators of tumorigenesis. Post-translational modification is the molecular switch that regulates protein function. Understanding how these mitochondria-related post-translational modification function during tumorigenesis will bring new ideas for the next generation of cancer treatment.
线粒体是细胞的“动力工厂”。近一个世纪的研究拓展了我们对线粒体的认识，远远超出了线粒体是细胞内重要的能量生成器这一观点。在肿瘤细胞的起始、生长和存活过程中，呼吸链和三羧酸循环的重要酶、线粒体生物发生和动力学、氧化应激调节和分子信号等方面都发生了显著的线粒体代谢变化。因此，线粒体代谢蛋白是肿瘤发生的关键介质。翻译后修饰是调节蛋白质功能的分子开关。了解这些与线粒体相关的翻译后修饰在肿瘤发生过程中的作用，将为下一代癌症治疗带来新的思路。
