Institut de Recherche pour le Développement, UMI233/INSERM U1175/Université de Montpellier, Montpellier, France.
Infectious Diseases Division, Washington University School of Medicine, St. Louis, Missouri.
Am J Trop Med Hyg. 2021 Dec 20;106(2):729-731. doi: 10.4269/ajtmh.21-0731.
Between October 2012 and October 2015, we conducted a community trial to assess the impact of semi-annual (twice yearly) community treatment with albendazole on lymphatic filariasis in Seke Pembe, a village in the Republic of the Congo. Semi-annual community treatment with albendazole has been continued in the community since October 2015. We conducted an additional parasitological assessment survey in October 2019, 6 months after the 14th round of semi-annual treatment. Between October 2012 and October 2015, Wuchereria bancrofti antigenemia and microfilaremia rates in the community had decreased from 17.3% to 4.7% and from 5.3% to 0.3%, respectively. In October 2019, the antigenemia rate had decreased further to 2.8% (19 of 687). No microfilariae were found in night blood smears from persons with circulating filarial antigenemia (0 of 16), suggesting that W. bancrofti transmission has been interrupted in Seke Pembe. Semi-annual albendazole treatments also reduced significantly infection rates with soil-transmitted helminths.
2012 年 10 月至 2015 年 10 月，我们在刚果共和国的 Seke Pembe 村进行了一项社区试验，以评估每半年（每年两次）用阿苯达唑进行社区治疗对淋巴丝虫病的影响。自 2015 年 10 月以来，该社区一直在继续进行半年度的阿苯达唑社区治疗。我们在 2019 年 10 月进行了另一项寄生虫学评估调查，即第 14 轮半年度治疗后 6 个月。2012 年 10 月至 2015 年 10 月期间，社区内班氏丝虫抗原血症和微丝蚴血症率分别从 17.3%降至 4.7%和从 5.3%降至 0.3%。2019 年 10 月，抗原血症率进一步降至 2.8%（687 人中 19 人）。在具有循环丝虫抗原血症的人夜间血涂片上未发现微丝蚴（16 人中有 0 人），表明 Seke Pembe 中断了班氏丝虫的传播。每半年一次的阿苯达唑治疗还显著降低了土壤传播性蠕虫的感染率。
