Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, 70112, USA.
Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, 33520, Tampere, Finland.
Clin Epigenetics. 2021 Dec 20;13(1):227. doi: 10.1186/s13148-021-01215-1.
Women with a history of complications of pregnancy, including hypertensive disorders, gestational diabetes or an infant fetal growth restriction or preterm birth, are at higher risk for cardiovascular disease later in life. We aimed to examine differences in maternal DNA methylation following pregnancy complications.
Data on women participating in the Young Finns study (n = 836) were linked to the national birth registry. DNA methylation in whole blood was assessed using the Infinium Methylation EPIC BeadChip. Epigenome-wide analysis was conducted on differential CpG methylation at 850 K sites. Reproductive history was also modeled as a predictor of four epigenetic age indices.
Fourteen significant differentially methylated sites were found associated with both history of pre-eclampsia and overall hypertensive disorders of pregnancy. No associations were found between reproductive history and any epigenetic age acceleration measure.
Differences in epigenetic methylation profiles could represent pre-existing risk factors, or changes that occurred as a result of experiencing these complications.
有妊娠并发症史的女性，包括高血压疾病、妊娠期糖尿病、胎儿生长受限或早产，以后发生心血管疾病的风险更高。我们旨在研究妊娠并发症后母体 DNA 甲基化的差异。
将参与 Young Finns 研究的女性（n=836）的数据与国家出生登记处进行关联。使用 Infinium Methylation EPIC BeadChip 评估全血中的 DNA 甲基化。在 850 K 个位点上进行了差异 CpG 甲基化的全基因组分析。生殖史也被建模为四个表观遗传年龄指数的预测因子。
发现 14 个与先兆子痫和整体妊娠高血压疾病病史相关的显著差异甲基化位点。生殖史与任何表观遗传年龄加速测量值之间没有关联。
表观遗传甲基化谱的差异可能代表预先存在的危险因素，或因经历这些并发症而发生的变化。
