Yavari P, Weight F F
Brain Res. 1987 Jan 1;400(1):133-8. doi: 10.1016/0006-8993(87)90660-3.
The effect of muscarinic antagonists was studied on the muscarinic slow IPSP (inhibitory postsynaptic potential) and slow EPSP (excitatory postsynaptic potential) in bullfrog sympathetic ganglia using the sucrose-gap recording method. Pirenzepine, alcuronium and atropine reduced slow IPSP amplitude more than slow EPSP amplitude. The most selective antagonists studied were pancuronium and gallamine which blocked or substantially reduced the slow IPSP without significantly affecting slow EPSP amplitude. The results suggest that the muscarinic inhibitory response may involve a different muscarinic receptor subtype, and/or receptor-ion-channel complex, than the muscarinic excitatory response.
采用蔗糖间隙记录法，研究了毒蕈碱拮抗剂对牛蛙交感神经节中毒蕈碱慢抑制性突触后电位（IPSP）和慢兴奋性突触后电位（EPSP）的影响。哌仑西平、阿库氯铵和阿托品降低慢IPSP幅度的程度大于慢EPSP幅度。所研究的最具选择性的拮抗剂是泮库溴铵和加拉明，它们阻断或显著降低慢IPSP，而对慢EPSP幅度无明显影响。结果表明，毒蕈碱抑制反应可能涉及与毒蕈碱兴奋反应不同的毒蕈碱受体亚型和/或受体-离子通道复合物。
