RORα 和 REV-ERBα 与临床病理参数相关，是胃癌预后的独立生物标志物。
RORα and REV-ERBα are Associated With Clinicopathological Parameters and are Independent Biomarkers of Prognosis in Gastric Cancer.
机构信息
36639The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China.
出版信息
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211039670. doi: 10.1177/15330338211039670.
Retinoid-related orphan receptor alpha (RORα) and nuclear receptor subfamily 1 group D member 1 (REV-ERBα) play critical roles in many human cancers. Whether RORα and REV-ERBα expression levels are associated with clinical characteristics are poorly understood, and they may be independent predictors of overall survival (OS) and progression-free survival (PFS) in gastric cancer (GC). This study aimed to investigate the correlation of RORα and REV-ERBα expression levels with clinicopathological parameters, OS, and PFS in GC. Immunohistochemistry and quantitative reverse transcription-polymerase chain reaction (qRT-PCR) were employed to assess the expression levels of RORα and REV-ERBα, which were downregulated in GC tissues compared with normal gastric tissues ( < .001; < .001) and were associated with several clinicopathological parameters, including histological grade ( = .032; < .001), preoperative carcinoembryonic antigen (CEA) levels ( = .004; < .001), and tumor-node-metastasis (TNM) stage ( = .015; < .001). Additionally, low RORα and REV-ERBα expression levels were associated with poor OS and PFS in GC patients, respectively ( < .001; = .001). Furthermore, univariate Cox regression model analysis showed that histological grade ( < .001; < .001), preoperative CEA levels ( < .001; = .001), TNM stage ( < .001; < .001), lymph node metastasis ( = .002; = .002), RORα expression levels ( = .001; < .001), and REV-ERBα expression levels ( < .001; = .001) were associated with OS and PFS in GC. Multivariate Cox regression model analysis indicated that RORα expression levels and REV-ERBα expression levels are independent factors of OS and PFS in GC. Besides, RORα and REV-ERBα expression may be positively correlated (χ = 6.835; = .009), and GC patients with both high RORα and REV-ERBα expression levels had the best prognosis. In conclusion, RORα and REV-ERBα may coparticipate in tumor activities and show potential to estimate the prognosis of GC.
视黄酸相关孤儿受体α（RORα）和核受体亚家族 1 组 D 成员 1（REV-ERBα）在许多人类癌症中发挥着关键作用。RORα 和 REV-ERBα 的表达水平是否与临床特征相关尚不清楚，它们可能是胃癌（GC）患者总生存期（OS）和无进展生存期（PFS）的独立预测因子。本研究旨在探讨 RORα 和 REV-ERBα 表达水平与 GC 临床病理参数、OS 和 PFS 的相关性。免疫组织化学和定量逆转录聚合酶链反应（qRT-PCR）用于评估 RORα 和 REV-ERBα 的表达水平，与正常胃组织相比，GC 组织中 RORα 和 REV-ERBα 的表达水平下调（<0.001；<0.001），与多个临床病理参数相关，包括组织学分级（=0.032；<0.001）、术前癌胚抗原（CEA）水平（=0.004；<0.001）和肿瘤-淋巴结-转移（TNM）分期（=0.015；<0.001）。此外，低 RORα 和 REV-ERBα 表达水平与 GC 患者的不良 OS 和 PFS 相关（<0.001；=0.001）。此外，单因素 Cox 回归模型分析显示，组织学分级（<0.001；<0.001）、术前 CEA 水平（<0.001；=0.001）、TNM 分期（<0.001；<0.001）、淋巴结转移（=0.002；=0.002）、RORα 表达水平（=0.001；<0.001）和 REV-ERBα 表达水平（<0.001；=0.001）与 GC 的 OS 和 PFS 相关。多因素 Cox 回归模型分析表明，RORα 表达水平和 REV-ERBα 表达水平是 GC 患者 OS 和 PFS 的独立影响因素。此外，RORα 和 REV-ERBα 表达可能呈正相关（χ2=6.835；=0.009），并且同时具有高 RORα 和 REV-ERBα 表达水平的 GC 患者预后最佳。综上所述，RORα 和 REV-ERBα 可能共同参与肿瘤活动，并具有评估 GC 预后的潜力。
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