硫酸海索那林（异丙喘定）治疗运动诱发性哮喘的评估

An evaluation of oral hexoprenaline sulphate (Ipradol) in exercise-induced asthma.

作者信息

Anderson S D, Spiroglou M, Lindsay D

出版信息

Med J Aust. 1977 Dec 17;2(25):825-7. doi: 10.5694/j.1326-5377.1977.tb99333.x.

DOI:10.5694/j.1326-5377.1977.tb99333.x

Abstract

The effect of hexoprenaline sulphate (1 mg) administered orally on the fall in peak expiratory flow rate (PEFR) after exercise was investigated in 20 asthmatic patients. Compared with placebo, the fall in PEFR expressed as a percentage of the resting value (measured immediately before exercise) was less in 16 of the 20 patients in the presence of hexoprenaline sulphate. This consistent amelioration of exercise-induced asthma has not been observed in this laboratory with similar drugs (such as salbutamol and terbutaline). While eight patients were afforded significant protection by the hexoprenaline sulphate, a fall in PEFR after exercise was within the normal range (less than 10% of the resting value) in only four patients.

摘要

在20名哮喘患者中研究了口服硫酸海索那林（1毫克）对运动后呼气峰值流速（PEFR）下降的影响。与安慰剂相比，在服用硫酸海索那林的情况下，20名患者中有16名患者的PEFR下降幅度以静息值（运动前即刻测量）的百分比表示较小。在本实验室中，使用类似药物（如沙丁胺醇和特布他林）未观察到这种对运动诱发哮喘的持续改善。虽然8名患者得到了硫酸海索那林的显著保护，但只有4名患者运动后的PEFR下降幅度在正常范围内（低于静息值的10%）。