Dhermy P, Leport M, D'Hermies F, Clay C, Lacombe E, Pouliquen Y
J Fr Ophtalmol. 1986;9(10):625-31.
Corneal dysplasia has been recently reported. Clinically, it is characterized by a progressive epithelial corneal opacity with pearly or greyish white coloration. Its topography may be either next to either far from the limbus. The recurrences are frequent after surgical treatment. Histologically, many aspects are described. Morphological changes affecting the cells and/or the architecture of the modified epithelium, may vary from light dysplasia to true carcinoma in situ. Some peculiar clinical conditions may coexist with corneal dysplasia, which may also be isolated. Three clinical cases are reported, with detailed pathological data. The signification of the use of the term "dysplasia" and the histogenesis are discussed, and the conclusions for treatment are drawn.
角膜发育异常最近已有报道。临床上，其特征为角膜上皮逐渐出现珍珠样或灰白色混浊。其形态学位置可紧邻或远离角膜缘。手术治疗后复发频繁。组织学上，有诸多方面的描述。影响细胞和/或改良上皮结构的形态学改变，可从轻度发育异常到原位癌不等。一些特殊临床情况可能与角膜发育异常并存，角膜发育异常也可能是孤立存在的。本文报告了3例临床病例，并给出了详细的病理数据。文中讨论了“发育异常”一词的使用意义及组织发生，并得出了治疗结论。
