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本文引用的文献

1
Correlation between PET/CT and CT in the staging prior to the treatment of head and neck squamous cell carcinoma.头颈部鳞状细胞癌治疗前的 PET/CT 与 CT 分期的相关性。
Braz J Otorhinolaryngol. 2021 Jan-Feb;87(1):11-18. doi: 10.1016/j.bjorl.2019.06.004. Epub 2019 Jul 6.
2
Predictive Value of First Posttreatment Imaging Using Standardized Reporting in Head and Neck Cancer.头颈部癌症首次治疗后使用标准化报告的影像学预测价值。
Otolaryngol Head Neck Surg. 2019 Dec;161(6):978-985. doi: 10.1177/0194599819865235. Epub 2019 Jul 23.
3
Nivolumab in Patients with Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck: Efficacy and Safety in CheckMate 141 by Prior Cetuximab Use.纳武利尤单抗治疗复发或转移性头颈部鳞状细胞癌患者:CheckMate 141 研究中既往接受西妥昔单抗治疗患者的疗效和安全性。
Clin Cancer Res. 2019 Sep 1;25(17):5221-5230. doi: 10.1158/1078-0432.CCR-18-3944. Epub 2019 Jun 25.
4
Imaging of Patients with Head and Neck Cancer: From Staging to Surveillance.头颈部癌症患者的影像学检查:从分期到监测
Oral Maxillofac Surg Clin North Am. 2018 Nov;30(4):421-433. doi: 10.1016/j.coms.2018.06.004. Epub 2018 Aug 22.
5
18F-FDG-PET/CT for the detection of disease in patients with head and neck cancer treated with radiotherapy.18F-氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描用于检测接受放射治疗的头颈癌患者的疾病。
PLoS One. 2017 Aug 3;12(8):e0182350. doi: 10.1371/journal.pone.0182350. eCollection 2017.
6
Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial.帕博利珠单抗治疗头颈部复发或转移性鳞状细胞癌的安全性和临床活性(KEYNOTE-012):一项开放标签、多中心、1b 期试验。
Lancet Oncol. 2016 Jul;17(7):956-965. doi: 10.1016/S1470-2045(16)30066-3. Epub 2016 May 27.
7
PET-CT Surveillance versus Neck Dissection in Advanced Head and Neck Cancer.PET-CT 监测与颈部清扫术在头颈部晚期癌症中的应用。
N Engl J Med. 2016 Apr 14;374(15):1444-54. doi: 10.1056/NEJMoa1514493. Epub 2016 Mar 23.
8
Evaluating the potential role of PET/CT in the posttreatment surveillance of head and neck cancer.评估正电子发射断层显像/计算机断层扫描(PET/CT)在头颈部癌治疗后监测中的潜在作用。
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9
Negative predictive value of surveillance PET/CT in head and neck squamous cell cancer.头颈部鳞状细胞癌监测 PET/CT 的阴性预测值。
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10
Impact of positron emission tomography/computed tomography surveillance at 12 and 24 months for detecting head and neck cancer recurrence.12 个月和 24 个月时正电子发射断层扫描/计算机断层扫描监测对头颈部癌症复发的影响。
Cancer. 2013 Apr 1;119(7):1349-56. doi: 10.1002/cncr.27892. Epub 2012 Dec 7.

头颈部鳞状细胞癌治疗后分期的 PET-CT 与 CT 的相关性。

Correlation between PET-CT and ct in the staging after the treatment of head and neck squamous cell carcinoma.

机构信息

Hospital Santa Bárbara, Department of Otorhinolaryngology, Soria, Spain.

Hospital Santa Bárbara, Department of Otorhinolaryngology, Soria, Spain.

出版信息

Braz J Otorhinolaryngol. 2022 Nov-Dec;88 Suppl 4(Suppl 4):S143-S151. doi: 10.1016/j.bjorl.2021.11.008. Epub 2021 Dec 7.

DOI:10.1016/j.bjorl.2021.11.008
PMID:34933818
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9756050/
Abstract

OBJECTIVE

The aim of this study is to find out if a single imaging test is enough to follow-up on an oncological post-treatment patient. In such a case, we would know which was more valuable after comparing the two, by CT or PET-CT.

METHODS

Between January 2012 and July 2018, we collected data from all patients with previous medical history who were treated with a head and neck squamous cell carcinoma in our hospital, through surgery or by using an organ preservation protocol which we had done. Patients were required to have a CT and a PET-CT performed in a maximum period of 30 days between techniques. We compared the post post-treatment stage given to each case by using only the physical examination (only the CT and the PET-CT), with the ones given by the Tumor Board. After treatment, we analysed the similarity through Cramer's V statistic test.

RESULTS

We performed a comparative analysis, obtaining a correlation of 0.426 between the stages given by the Tumor Board and the one assigned based on physical examination, without imaging techniques. By only using the computed tomography as an imaging method the correlation was 0.565, whereas with only the use of positron emission computed technology, it was estimated at 0.858. When we compared the statistical association between stages using exclusively one of the two imaging techniques, the correlation was 0.451.

CONCLUSION

Independent of the modality, we have demonstrated that in patients who have received previous treatment, there was a higher correlation in the stages with respect to the diagnostic method conducted by the Tumor Board using PET-CT as the sole image.

LEVEL OF EVIDENCE

Level 1.

摘要

目的

本研究旨在探讨单一影像学检查是否足以随访肿瘤治疗后的患者。如果可以,我们将通过比较 CT 和 PET-CT 来确定哪种检查更有价值。

方法

我们收集了 2012 年 1 月至 2018 年 7 月期间在我院接受头颈部鳞癌治疗(手术或采用我们制定的器官保留方案)的所有患者的病史数据。患者在 30 天内最多需要进行一次 CT 和一次 PET-CT 检查。我们通过仅使用体格检查(仅 CT 和 PET-CT)和肿瘤委员会来比较每个病例的治疗后阶段,并通过 Cramer's V 统计检验来分析相似性。

结果

我们进行了对比分析,发现肿瘤委员会给出的阶段与仅通过体格检查分配的阶段之间存在 0.426 的相关性。仅使用计算机断层扫描作为影像学方法时,相关性为 0.565,而仅使用正电子发射断层扫描时,相关性估计为 0.858。当我们仅使用两种影像学技术中的一种比较阶段之间的统计关联时,相关性为 0.451。

结论

无论采用哪种方式,我们都证明了在接受过治疗的患者中,使用 PET-CT 作为唯一图像的肿瘤委员会诊断方法的阶段相关性更高。

证据水平

1 级。