Harrison A, Royle L
NCI Monogr. 1987(3):157-8.
The short-lived isotope 211At (half-life, 7.2 hr), an alpha particle-emitting halogen, has been attached to a monoclonal antibody (anti-thy 1.1, IgG1, OX7) and used in mice in the treatment of a thy 1.1 T-cell lymphoma (A120). Forty-eight hours after receiving an iv injection of 10(3) or 10(5) A120 cells, mice were treated with phosphate-buffered saline, 211At-, antibody alone, or 211At conjugated to OX7. Treatment with the 211At-labeled OX7 conjugate increased the median survival time of mice and probably "cured" (survival at 200 days) 6 of the 15 mice given 10(5) cells and 21 of the 27 mice given 10(3) cells.
短寿命同位素砹211（半衰期7.2小时）是一种发射α粒子的卤素，已与单克隆抗体（抗Thy 1.1，IgG1，OX7）结合，并用于小鼠体内治疗Thy 1.1 T细胞淋巴瘤（A120）。在静脉注射10³或10⁵个A120细胞48小时后，用磷酸盐缓冲盐水、单独的砹211、单独的抗体或与OX7偶联的砹211对小鼠进行治疗。用砹211标记的OX7偶联物治疗可延长小鼠的中位生存时间，并且在给予10⁵个细胞的15只小鼠中有6只、给予10³个细胞的27只小鼠中有21只可能被“治愈”（存活200天）。
