Levi A C, Debernardi C
Minerva Stomatol. 1977 Jul-Sep;26(3):105-12.
Gingival crest melanocytes were examined in partial and total edentulates (with and without prostheses). Where the epithelium showed signs of epidermisation, the cells displayed their normal form and melanogenetic activity. In the presence of involution (acanthosis, reduction of the surface layers, smallcell infiltration), they withdrew their typical cytoplasmic expansion, while the Dopa reaction revealed poor thyrosinase activity. It is felt that these patterns confirm the epithelio-melanocyte symbiosis theory put forward by Quevedo et al. One total edentulate with a mucosally supported prosthesis displayed Dopa-positive dendritic cells on the gingival corium and tunica propria. These are seen as true melanocytes that had migrated from the epithelium.
对部分无牙颌和全口无牙颌患者（佩戴和未佩戴假牙）的龈嵴黑素细胞进行了检查。在上皮出现表皮化迹象的部位，细胞呈现正常形态并具有黑素生成活性。在出现退化（棘皮症、表层减少、小细胞浸润）的情况下，它们撤回了典型的细胞质扩张，而多巴反应显示酪氨酸酶活性较差。人们认为这些模式证实了Quevedo等人提出的上皮-黑素细胞共生理论。一名佩戴黏膜支持式假牙的全口无牙颌患者的牙龈真皮层和固有层出现了多巴阳性树突状细胞。这些被视为从上皮迁移而来的真正黑素细胞。
