Department of Neonatology, Children's Hospital of Fudan University, Shanghai, China.
NHC Key Laboratory of Neonatal Diseases, Fudan University, Shanghai, China.
Breastfeed Med. 2022 Apr;17(4):326-330. doi: 10.1089/bfm.2021.0298. Epub 2021 Dec 17.
Necrotizing enterocolitis (NEC) is a severe intestinal disease that often occurs in preterm infants, and there currently is a lack of specific and effective therapy. Human milk is rich in cells that may become a potential NEC treatment. To evaluate the safety and feasibility of cell-enriched fresh human milk treatment for premature infants with stage I NEC. Infants born at <1,500 g birth weight who developed stage I NEC were enrolled. Along with routine treatment for these infants, those in the intervention group were treated with cell-enriched fresh mother's milk (1 mL/kg) once per day for seven consecutive days. The intervention feasibility and safety were monitored and evaluated as primary outcomes. Short-term outcomes, including the duration of antibiotics, days to full enteral feeding and prognosis, were investigated as secondary outcomes. Forty infants were enrolled, and 20 infants were included in each group. The demographic characteristics of the two groups of infants were comparable. All infants in the intervention group completed cell-enriched fresh mother's milk feeding for 7 days without any adverse clinical issues. The infants' vital signs were within the normal range during and after the intervention. None of the enrolled patients progressed to stage II NEC or above. The time interval from milk pumping to feeding was 3.7 ± 0.5 hours. Using cell-enriched fresh mother's milk to treat premature infants with stage I NEC was safe and feasible.
坏死性小肠结肠炎（NEC）是一种严重的肠道疾病，常发生于早产儿，目前缺乏特异性和有效的治疗方法。人乳富含可能成为潜在 NEC 治疗方法的细胞。评估富含细胞的新鲜人乳治疗Ⅰ期 NEC 早产儿的安全性和可行性。纳入出生体重<1500g 且发生Ⅰ期 NEC 的早产儿。除了对这些婴儿进行常规治疗外，干预组还每天接受富含细胞的新鲜母乳（1mL/kg）治疗，连续 7 天。主要结局为监测和评估干预的可行性和安全性。次要结局为短期结局，包括抗生素使用时间、完全肠内喂养时间和预后。共纳入 40 例婴儿，每组 20 例。两组婴儿的人口统计学特征具有可比性。干预组所有婴儿均完成了 7 天的富含细胞的新鲜母乳喂养，无任何不良临床问题。干预期间和干预后婴儿的生命体征均在正常范围内。无患者进展为Ⅱ期 NEC 或更高级别。从吸奶到喂养的时间间隔为 3.7±0.5 小时。使用富含细胞的新鲜母乳治疗Ⅰ期 NEC 早产儿是安全且可行的。
